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Gandhi Medicos Hepatitis C is a disease that is increasingly common in young people’s history. It is impossible to protect yourself from infection, the vaccine is not working from this gravest disease in the world. However, new drugs compete well with the symptoms of this ailment. Harvoni is one of the most reliable medicines of the new generation.

Where to buy Harvoni and what is the price of the drug

For the treatment of hepatitis C, Harvoni is most often used abroad. It was approved for use in the largest clinics in Israel, the United States, and Europe. However, at the moment it cannot be found in pharmacies of the CIS countries. Here you can buy the drug Harvoni in private clinics that have a manufacturer’s certificate. Deliver it from European countries, most often from Germany.

The price for Harvoni is quite high all over the world. For example, in Germany, the treatment of this drug costs about 20 thousand euros, and in the US – about 25 thousand dollars a month. 12 weeks of Harvoni treatment in Israel for insurance costs about 90 thousand dollars.

Like many other new and expensive drugs, Harvoni has their own copies – generics. They are manufactured mainly in Bangladesh. “Lezovir-C”, as well as “Twinvir” allows undergoing treatment to a wide range of patients. Asian firms are soon planning to enter the European market with cheap generics Harvoni against hepatitis C. You can buy Harvoni at the official online store of the supplier.

Composition of the drug Harvoni

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To date, the drug Harvoni is the best method to combat hepatitis C of the first genotype. The uniqueness of this type of treatment is that the patient does not need to add ribavirin or interferon to the therapy. This is the third drug in the world, the clinical effect of which was confirmed at a conference on retroviruses in 2013.

This medicine was developed and patented by the American biotechnology firm Gilead Sciences in 2014. The Harvoni tablet has a diamond shape, an orange color and is covered with a special glaze. The active substance is ledipasvir (in a dosage of 90 mg), as well as sofosbuvir (400 mg).

The combination of these components has the strongest antiviral effect, which does not leave the hepatitis C virus a chance to replicate. Additional substances include lactose monohydrate, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, copovidone. The

a glaze of this preparation consists of a number of substances, including talc, macrogol and titanium dioxide.

The effectiveness of treatment of hepatitis C with Harvoni

When the main components of the drug Harvoni get into the patient’s body, they begin to block the enzymes responsible for the replication of the hepatitis C virus. This treatment has been repeatedly tested by trial.

More than 1300 people with hepatitis C participated in the tests. All participants were divided into two groups. Representatives of one group have already been treated, the second – just started. The experiment lasted about twelve weeks.

The first group was given to the drug Harvoni, as well as ribavirin. The second received also Harvoni, but without ribavirin. The goal of scientists was to prove the validity of their invention and the clinical result after a full course of administration of the drug.

The results were as follows:

  1. After 8 weeks, 95% of people who were first treated for the disease, fully recovered.
  2. After 12 weeks their number has increased to 97%.
  3. 99% of people who came to the experiment with cirrhosis completely recovered after 12 weeks.

Thus, the years of work on the drug were not in vain, the effectiveness of the drug without the use of ribavirin was proved. Reviews Harvoni received mostly positive, but some experienced a side effect in the form of headaches and nausea.

Indications for use Harvoni

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The drug Harvoni is necessary for patients suffering from hepatitis C of the first genotype. This kind of virus is the most common. Nevertheless, his treatment so far has been incredibly difficult. By adapting, the virus produces a specific immunity to antibiotics.

In total, the hepatitis C virus has six genotypes, and those, in turn, have subgroups. This number of “mutations” makes the virus resistant to our immunity and various medications.

During the diagnosis it is very important to determine the genotype of the virus, it will help to choose the therapy faster. The drug Harvoni prescribed for patients who have cirrhosis, as well as without it. In more than 90% of cases of hepatitis C, the first genotype develops a chronic form.

Only 10-15% of people independently and completely recover from a viral illness, while others are carriers and are dangerous to surrounding people. Most often, patients are prescribed interferon as the main drug. However, it has a number of contraindications, as well as side effects (bronchial spasms, swelling, anaphylactic shock).

Harvoni can be included in therapy to people who have only been diagnosed and begin treatment. It will be effective for those who unsuccessfully struggled with the disease for years. It can be used for those who have allergic reactions to common methods of treatment with ribavirin, as well as interferon.

Harvoni is prescribed if the patient is over 18 years of age, and the index of his body weight is more than 18 kg per m 2. The concentration of viral RNA should be more than 10 000 IU in the patient’s plasma.

Contraindications to the use of Harvoni

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Like any drug, Harvoni has a number of contraindications. During the delivery of blood for the presence of hepatitis C RNA, as well as the genotype of the virus, the treating physician should interview the patient for allergic reactions to certain components of the drug.

Contraindications Harvoni also are:

  • Pregnancy and lactation.
  • Age to 18 years.
  • The use of another drug, which contains sofosbuvir. There is a risk that the patient will have an excessive amount of this substance, which leads to chemical poisoning.
  • Use of drugs with tenofovir.
  • Taking medications containing tipranavir and carbamazepine. These substances and components can neutralize the antiviral effect of the drug.

Before starting a course of treatment, you need to undergo examinations for the presence of kidney or liver failure. Such diagnoses often accompany hepatitis. Treatment Harvoni, in this case, is possible, but under the strict supervision of the therapist and narrow specialists.

It is worth taking a responsible choice of contraception since pregnancy is not recommended during the period of treatment. There are no known risks of influencing the fetus. It is also necessary to refrain from breastfeeding since Harvoni penetrates with the milk into the baby’s body. Doctors never prescribe a drug to children under the age of eighteen, since its effect on the immature organism has not been studied so far.

How to take Harvoni in the treatment of hepatitis C

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The European Association for the Study of the Liver (EASL) has developed an instruction for the application of Harvoni. Every day you need to take one tablet of the drug while eating. Do not chew, crush or dissolve it. Like many other medicines, Harvoni gives the best effect with regular intake at one time. Therefore, it is better to choose the optimal time of taking the pill from the very beginning of the course.

Doctors recommend that you follow these rules of reception:

  1. If you forget for some reason to drink a pill in a timely manner, drink later. You can only skip one dose.
  2. Drinking two doses in a row is by no means possible.
  3. You need to drink Havroni even when you feel fatigue or headaches.

The scheme of taking the medicine is quite simple. The course of treatment is small. For patients with hepatitis C of the first genotype, it is only twelve weeks. If you have cirrhosis of the liver, treatment should be prolonged twice (24 weeks). It is also necessary to act for those who have already been treated with other drugs, and it was ineffective.

Each patient should clarify the instructions for the application of Harvoni from his attending physician, since the duration may depend on the individual characteristics of the organism.

After completing the full course of treatment, a detailed examination is necessary. If the therapeutic effect is not achieved, re-administer the treatment of Harvoni does not make sense. The lack of primary efficacy is an incentive to look for other treatment options.

The scheme of reception of Harvoni differs in case the patient has an additional viral infection, which often accompanies hepatitis C – HIV. It is individually developed by a virologist.

For the first, fourth, fifth or sixth genotypes, the treatment time is 12 weeks in combination with ribavirin, Sofosbuvir, and Ledipasvir. Without ribavirin – 24 weeks. Ribavirin, in this case, helps to reduce the duration of treatment, and hence the cost of the course of therapy.

Side effects from the application of Harvoni

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Side effects from Harvoni occur infrequently but can occur. As a rule, these are migraines and headaches, fast fatigue and lethargy, allergic manifestations (rarely).

If you are using HARVONI for the first time, you should be careful and listen to your own body. Suspicions should cause symptoms such as shortness of breath, swelling, severe itching over the body. In such cases, therapy is interrupted instantly. After consultation with the virologist, a new drug regimen is prepared.

Many doctors who lead patients with hepatitis C, notice the typical effects after the start of the drug (malaise, insomnia, lethargy). But do not panic. An experienced doctor will be able to assess the risks of applying Harvoni and advise the individual scheme of admission.

When applying Harvoni along with ribavirin, the risks of side effects are much higher. Cirrhosis of the liver can also become a factor in the development of complications, but there are no direct contraindications. In 90% of cases, the drug is tolerated calmly and gives a relatively quick recovery.

Harvoni does not affect the concentration of attention because you can drive a car during treatment. However, it is worthwhile to be alert: body fatigue can negatively affect the brain.

There is no need for special changes in the Harvoni reception course for the elderly after age 65. They are prescribed the usual dose of medicine.

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