Interactions with food and medicine: regardless of food intake. Dolutegravir can significantly increase the concentration of drugs, the removal of which depends on OCT2 (mofetil, metformin), combined with an antsidami and iron preparations should be carried out at least 2 hours before or 6 hours after prim dolutegravir, taking rifampicin requires dose adjustment.
The most significant side effects: sleep disorders, headaches, nausea, diarrhea, rash, itchy skin. Hypersensitivity reactions, violations of liver function in co-infected with viral hepatitis B and C.
Contraindications: hypersensitivity to dolutegravir or any other component of the drug, simultaneous use with dofetilide, children under 12 years of age and body weight of less than 40 kg.