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Capecitabine is used in the treatment of ovarian cancer, head and neck cancer, cervical cancer, testicular cancer., breast cancer, non-Hodgkin lymphoma (NHL), blood cancer, lung cancer, bone cancer and urinary bladder cancer

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Capecitabine is used

Treating certain types of breast, colon, or colorectal cancer in some patients. It may be used alone or with other medicines in some cases.

Capecitabine is an antimetabolite. It works by interfering with the production of proteins necessary for cancer cell growth and reproduction.

Do NOT use capecitabine if:

  • you are allergic to any ingredient in capecitabine or to 5-fluorouracil
  • you have severe kidney problems or you have been told that you lack the enzyme dihydropyrimidine dehydrogenase (DPD)

Contact your doctor or health care provider right away if any of these apply to you.

Before using capecitabine:

Some medical conditions may interact with capecitabine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription (particularly blood thinners) or nonprescription medicine, herbal preparation, or dietary supplement (vitamin E, aspirin, ibuprofen, naproxen)
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart, kidney, or liver problems; bone marrow problems; or pain, redness, swelling, tingling, or tenderness of the palms of the hands or soles of the feet (hand-and-foot syndrome)
  • if you have nausea, vomiting, diarrhea, inflammation or sores in the mouth, or an infection
  • if you are undergoing chemotherapy or radiation therapy, or if you take folic acid or vitamins that contain folic acid

Some MEDICINES MAY INTERACT with capecitabine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Certain anticoagulants (eg, phenprocoumon, warfarin) because the risk of bleeding may be increased by capecitabine
  • Leucovorin because the risk of severe intestinal problems, diarrhea, and dehydration may be increased
  • Hydantoins (eg, phenytoin) because their side effects may be increased by capecitabine

This may not be a complete list of all interactions that may occur. Ask your health care provider if capecitabine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use capecitabine:

Use capecitabine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with capecitabine. Talk to your pharmacist if you have questions about this information.
  • Take capecitabine with food or within 30 minutes after a meal.
  • Swallow capecitabine whole with water. Do not break, crush, or chew before swallowing.
  • It is recommended to use gloves and safety glasses to avoid exposure in case a tablet breaks. If powder from a broken tablet comes into contact with skin, wash the skin immediately with soap and water. If powder comes into contact with your mouth, nose, or eyes, rinse thoroughly with water.
  • If you miss a dose of capecitabine, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Check with your doctor if you miss a dose.

Ask your health care provider any questions you may have about how to use capecitabine.


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