Hepcinat LP | Buy Hepcinat LP Online Tablets price (Ledipasvir 90mg and Sofosbuvir 400mg)

Brand name: Hepcinat LP
Contents: Ledipasvir and Sofosbuvir
Manufactured by: Natco Pharma Ltd.
Form: Tablets
Strength: Ledipasvir 90 mg and
Sofosbuvir 400 mg
Packing: Pack of 28 tablets


Entering the medical market of the drug of the new generation of Harvoni marked a new stage in the worldwide fight against viral hepatitis. The international antiviral program has given the chance to conduct therapy even to the most socially unprotected layers of the population! Thanks to generics, the treatment scheme for the disease has become much easier, and the rehabilitation period is shorter. One of the effective analogs of Harvoni was the generic Hepcinat LP

Composition and pharmacological action of the drug Hepcinat LP

In its composition, the generic Hepcinat LP is a combination. It contains such substances: Ledipasvir in a dosage of 90 mg, Sofosbuvir in a dosage of 400 mg.

Two of these substances, when ingested into the body of an infected person, block specific enzymes that cause the hepatitis C virus to replicate and replicate (copy cells). Hepcinat LP also contains additional constituents: colloidal silicon dioxide, cellulose particles, magnesium stearate, croscarmellose sodium, copovidone.

The composition of the tablets Hepcinat LP a includes such inactive substances: iron oxide (yellow), polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide.

Each tablet has the shape of an oval of yellow color and covered with a special glaze. On one side, the tablet has the inscription “LP”, on the other side there is no inscription. In each brand jar, there are 28 tablets, as well as a gel made of silicate, which absorbs moisture. The originality of the products is also confirmed by the presence of a sealant, for example, made of polyester. A jar of Hepcinat LP a is necessarily equipped with a protective cover for children.

Before the invention of direct-acting drugs, hepatitis C patients usually received a combined treatment of Sofosbuvir, interferon, and ribavirin. Such therapy was ineffective – only 40% of the infected were cured. In addition, she had a number of side effects caused by a general intoxication of the body (nausea, migraine, spasms).

Hepcinat is highly effective due to the content of two active components. Clinical studies have shown that 95% of those who received therapy with this generic was able to fully recover. Tests were conducted on two groups. The first group was completely healthy, the second group had hepatitis C in a chronic stage.

Taking this drug orally, patients received an average concentration of substances in the body in four to four and a half hours. The carried out researches also have fixed, that the preparation does not influence processes of an oxidative metabolism in a body of the healthy person.

Instructions for the use of Hepcinate Lp

The instructions to Hepcinat indicate that it is recommended to take one tablet of the drug while eating. Food at the same time can be moderately high calorie, that is 600 calories or 25-20% fat; high-calorie – 1000 calories or 50% fat.

Adoption of this medication on an empty stomach does not reduce the antiviral effect. It is important to know that Hepcinat LP tablets do not need to be crushed, divided into parts or diluted with water. Try to take them at the same time every day. Such a system not only helps you not to forget about taking the pill but will also be more effective, due to the constant content of active substances in the body.

If you suddenly forget to take the necessary dose of Hepcinat LP, do not drink two tablets at the same time, it threatens with poisoning and anaphylactic shock!

This drug is prescribed for patients with hepatitis C of the first genotype. The risks of relapse after a full course of treatment depend on the initial situation:

  • Degrees of disease;
  • Presence of cirrhosis of the liver;
  • Presence of accompanying viruses;
  • The presence of AIDS or HIV infection.

Patients who undergo antiviral therapy for the first time are usually prescribed a course of treatment of 12 weeks, regardless of the presence or absence of cirrhous liver damage. If the viral load in the body of the primary patient is less than 6 million units/ml, the course of treatment can be reduced to eight weeks.

Those treated who have already been on antiviral medication (ribavirin or interferon), and it was not successful, are given 12 weeks of taking Hepcinat LP. If patients have already been treated earlier and have cirrhosis, the treatment is prolonged twice (24 weeks).

Recommendations for a group of patients who have severe disorders in kidney function, as well as kidney failure, because of the increased concentration of the main component of Sofosbuvir are absent.

Contraindications to the use of Hepcinat LP

There were no studies on contraindications to the inclusion of Hepcinat in antiviral therapy, but it is worth following the instructions for using the original version of the drug – Harvoni.

Contraindications Hepcinat following:

  1. Allergy to any component (not even the main one) in the medication;
  2. Pregnancy or lactation period;
  3. Age to 18 years;
  4. When taking another medication, which has in composition Sofosbuvir, an overdose of components is possible.

Also, Hepcinat LP should not be used if the patient is taking the following medicines: Carbamazepine, Rosuvastatin, St. John’s Wort, Rifampin, Tipranavir, Phenytoin, Elvitegravir, Tenofovir, Emtricitabine. These components may adversely affect the therapeutic effect of the Hepcinat LP drug.

Precautions for the treatment with generic Hepcinat LP

During the research of generic Hepcinat LP, there were periodic cases of bradycardia (slowing the rhythm of the heart), and also cases of cardiac arrest were recorded. In the case when the patient takes Amiodarone simultaneously with Hepcinat LPum, heart problems may also occur that require the use of pacemakers.

Slowing the rhythm of the heart was observed, most often, throughout the day, but there were also cases of bradycardia a week after the initiation of antiviral therapy for hepatitis C.

The following patients are at risk:

  • Accepting beta-blockers;
  • Taking drugs to stimulate the heart;
  • Have liver disease in the severe stage of development (cirrhosis).

After stopping the acceptance of generic Hepcinat LP as an antiviral therapy, the symptoms of heart failure stopped. Therefore, before you start a course of treatment with direct-acting drugs or their generics, be sure to undergo a full medical examination and a consultation with a therapist.

If treatment with Hepcinat lp and Amiodarone is impossible, doctors use the following scheme:

  1. To begin with, you need to consult a patient and warn him about the possible consequences.
  2. The inclusion of cardiac monitoring in stationary conditions on the first day of the combination Hepcinat LP + Amiodarone is used.

In the early days of taking the generic Hepcinat LP, you need to carefully monitor the slightest changes in the body’s condition. Suspicion of intoxication can cause the following symptoms: shortness of breath, constant fatigue, lethargy in the body, migraines, and headaches, pain in the heart area, mental disorders (disorientation in space and time), memory problems.

Side effects of Hepcinat LP?

Most often, patients who take Hepcinat LP, complain about the following side effects:

  • Headaches and general fatigue (in more than 10% of cases);
  • Nausea (6% for 8 weeks, 7% for 12 weeks and 9% for 24 weeks);
  • Diarrhea (4%, 3%, 7%, respectively);
  • Problems with sleep (3%, 5%, 6%, respectively).

When taking regular tests, 3% had bilirubin increased at week 8, less than 1% at week 12, and about 2% at week 24. It is also possible to increase lipase, which occurs without symptoms.

Side effects of the use of Hepcinat in pregnant women are unknown because clinical studies have not been conducted. However, scientists conducted tests on experimental rats. At the maximum dose of application of this drug, no effects on fetal development have been recorded.

Also, the reaction of the child’s organism, which feeds on the milk of the mother undergoing therapy, is not fully understood. In tests that were performed on rats, the baby plasma was fixed with lopinavir. However, he had no pronounced effect on them. Side effects of the drug Hepcinat LP for a child should be considered along with the risks of developing chronic hepatitis in the mother, as well as the possible effects of having the drug in the milk for feeding.

The adverse effects of Hepcinat LP in children under 18 years of age are not known. Studies that have been conducted with a group of volunteers from 18 to 80 years have proven that age does not have a clinical effect on the action of the drug Hepcinat LP.

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ledipasvir and sofosbuvir


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