Why is this medication prescribed?
Daclatasvir is used along with another medication (sofosbuvir [Solvadi]) to treat a certain type of chronic hepatitis C (an ongoing viral infection that damages the liver). Daclatasvir is in a class of antiviral medications called hepatitis C virus (HCV) NS5A inhibitors. It works by stopping the virus that causes hepatitis C from spreading inside the body. It is not known if daclatasvir prevents the spread of hepatitis C to other people.
How should this medicine be used?
Daclatasvir comes as a tablet to take by mouth. It is usually taken with or without food once a day. Daclatasvir must be taken in combination with sofosbuvir, usually for 12 weeks. Take daclatasvir at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take daclatasvir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take daclatasvir even if you feel well. Do not stop taking daclatasvir or sofosbuvir without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking daclatasvir,
- tell your doctor and pharmacist if you are allergic to daclatasvir, any other medications, or any of the ingredients in daclatasvir tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenytoin (Dilantin, Phenytek), and rifampin (Rifadin, Rimactane, in Rifamate, Rifater), Your doctor will probably tell you not to take daclatasvir if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone); certain antibiotics such as clarithromycin (Biaxin, in Prevpac), ciprofloxacin (Cipro), erythromycin (E.E.S., Eryc, PCE, others), nafcillin, rifapentine (Priftin), and telithromycin (Ketek); certain antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (noxafil), and voriconazole (Vfend); bosentan (Tracleer); certain cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor); dabigatran (Pradaxa); dexamethasone; digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Diltzac, Taztia, Tiazac); efavirenz (Sustiva, in Atripla), etravirine (Intelence); certain HIV protease inhibitors such as atazanavir (Reyataz, in Evotaz), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, Technivie, Viekira Pak), and saquinavir (Invirase); modafinil (Provigil); nefazodone; and verapamil (Calan, Covera-HS, Verelan, in Tarka). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with daclatasvir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor what herbal products you are taking, especially St. John’s wort. Your doctor will probably tell you not to take St. John’s wort while taking daclatasvir.
- tell your doctor if you have had a liver transplant.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking daclatasvir, call your doctor.
What special dietary instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.
What should I do if I forget a dose?
If you remember the missed dose on the day that you were supposed to take it, take the missed dose as soon as you remember it on that day. However, if you do not remember the missed dose until the next day, skip the missed dose and continue your regular dosing schedule. Do not take two doses on the same day.
What side effects can this medication cause?
Daclatasvir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you are also taking amiodarone and you experience any of these symptoms, call your doctor immediately:
- near fainting or fainting
- dizziness or lightheadedness
- weakness or not feeling well
- shortness of breath
- chest pain
- memory problems
Daclatasvir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.