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Irinotecan is an inhibitor of Topoisomerase, an enzyme important for replication of genetic material (DNA) in the cancer cells. Thus it stops the growth and multiplication of cancer cells

Product Description

Why is this medication prescribed?

Irinotecan is used alone or in combination with other medications to treat colon or rectal cancer (cancer that begins in the large intestine). Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It works by stopping the growth of cancer cells.

How should this medicine be used?

Irinotecan comes as a liquid to be given over 90 minutes intravenously (into a vein) by a doctor or nurse. It is usually given not more often than once a week, according to a schedule that alternates one or more weeks when you receive irinotecan with one or more weeks when you do not receive the medication. Your doctor will choose the schedule that will work best for you.

Your doctor may need to delay your treatment and adjust your dose if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with irinotecan.

Your doctor may give you medication to prevent nausea and vomiting before you receive each dose of irinotecan. Your doctor may also give you other medication(s) to prevent or treat other side effects.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

Other uses for this medicine

Irinotecan is also sometimes used along with other medications to treat small cell lung cancer. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving irinotecan,

  • tell your doctor and pharmacist if you are allergic to irinotecan, sorbitol, or any other medications.
  • tell your doctor if you are taking ketoconazole (Nizoral). Your doctor will probably tell you not to take ketoconazole for one week before you begin your treatment with irinotecan or during your treatment.
  • tell your doctor if you are taking St. John’s wort. You should not take St. John’s wort for 2 weeks before you begin your treatment with irinotecan or during your treatment.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention any of the following: atazanavir (Reyataz); gemfibrozil (Lopid); medications for seizures such as carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital (Luminal), phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifamate and Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had diabetes; fructose intolerance (inability to digest the natural sugar found in fruit); or liver, lung, or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant while you are receiving irinotecan. Talk to your doctor about birth control methods that will work for you. If you become pregnant while receiving irinotecan, call your doctor. Irinotecan may harm the fetus.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving irinotecan.
  • you should know that irinotecan may make you dizzy or affect your vision, especially during the first 24 hours after you receive a dose. Do not drive a car or operate machinery until you know how this medication affects you.
  • talk to your doctor before you receive any vaccinations during your treatment with irinotecan.

What special dietary instructions should I follow?

Your doctor will tell you about a special diet to follow to help control diarrhea during your treatment. Follow these instructions carefully.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while receiving this medicine.

What side effects can this medication cause?

Irinotecan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • constipation
  • swelling and sores in the mouth
  • heartburn
  • loss of appetite
  • weight loss
  • hair loss
  • weakness
  • sleepiness
  • pain, especially back pain

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  • chest pain
  • yellowing of the skin or eyes
  • swollen stomach
  • unexpected or unusual weight gain
  • swelling of the arms, hands, feet, ankles, or lower legs
  • rash
  • hives
  • itching
  • difficulty breathing or swallowing


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