Leucovorin 50mg injection is used in the treatment of ovarian cancer, blood cancer, hemorrhagic cystitis and methotrexate toxicity
How it works
Leucovorin 50mg injection enters the cells as 5-methyl tetrahydrofolate and supplies the cofactor blocked by methotrexate. It stabilises the binding of 5-dUMP and thrymidylate synthetase, enhances flourouracil activity and neutralises the effects of folic acid antagonists such as methotrexate but increases those of 5-fluorouracil.
Common side effects
Nausea, Vomiting, Diarrhoea, Mucosal inflammation