MOZIFOR

MOZIFOR

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Mozifor (plerixafor injection) is indicated in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells (HSCs) to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin’s lymphoma (NHL) and multiple myeloma (MM)

Product Description

Indication
Mozifor (plerixafor injection) is indicated in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells (HSCs) to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin’s lymphoma (NHL) and multiple myeloma (MM).
Important Safety Information for Mozifor (plerixafor injection)
Severe, life-threatening allergic reactions (anaphylaxis) can happen in people who take Mozifor. Tell your doctor right away if you experience hives (itchy raised bumps), eye swelling, or trouble breathing.
Mozifor is not intended for hematopoietic stem cell transplantation (HSCT) mobilization and collection in patients with leukemia.
Mozifor in combination with G-CSF increases circulating white blood cells (WBCs). Your WBC counts will be monitored.
Thrombocytopenia (a decrease in the number of platelets circulating in the blood) has been observed in patients receiving Mozifor. Your platelet counts will be monitored.
Cancer cells may be released from the bone marrow and subsequently collected along with your stem cells during apheresis. The potential effects of infusing cancer cells during your transplant have not been well-studied.
Your spleen may be examined if you experience pain in the left upper stomach area or left shoulder area as these may be signs of an enlarged or burst (ruptured) spleen.
Mozifor may harm the unborn child when administered to a pregnant woman.  The safety of Mozifor in pregnant women has not been established in clinical trials. If you are of childbearing potential you should be advised to avoid becoming pregnant while receiving treatment with Mozifor. If this drug is used during pregnancy, or if you become pregnant while taking this drug, you should be apprised of the potential hazard to the unborn child.

Get emergency medical help if you have any of these signs of an allergic reaction to Mozifor: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have a serious side effect such as:

  • easy bruising or bleeding, unusual weakness;
  • feeling like you might pass out; or
  • pain in your upper stomach, spreading to your shoulder or back.

Less serious side effects may include:

  • nausea, vomiting;
  • diarrhea, constipation;
  • dry mouth, numbness in or around your mouth;
  • upset stomach, bloating, gas;
  • tired feeling, trouble sleeping;
  • headache, dizziness;
  • joint or muscle pain;
  • increased sweating; or
  • itching, rash, or other irritation where the medication was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

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