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RESOF

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Sofosbuvir is used along with ribavirin (Copegus, Rebetol) and sometimes another medication (peginterferon alfa [Pegasys] to treat chronic hepatitis C (an ongoing viral infection that damages the liver). Sofosbuvir is also used along with ribavirin (Copegus, Rebetol) in people with liver cancer and hepatitis C infection who are waiting for a liver transplant to treat hepatitis C infection and to decrease the risk of reinfection after the transplant. Sofosbuvir is in a class of antiviral medications called nucleotide polymerase inhibitors. It works by decreasing the amount of hepatitis C virus (HCV) in the body. Sofosbuvir may not prevent the spread of hepatitis C to other people.

Product Description

Why is this medication prescribed?

Sofosbuvir is used along with ribavirin (Copegus, Rebetol) and sometimes another medication (peginterferon alfa [Pegasys] to treat chronic hepatitis C (an ongoing viral infection that damages the liver). Sofosbuvir is also used along with ribavirin (Copegus, Rebetol) in people with liver cancer and hepatitis C infection who are waiting for a liver transplant to treat hepatitis C infection and to decrease the risk of reinfection after the transplant. Sofosbuvir is in a class of antiviral medications called nucleotide polymerase inhibitors. It works by decreasing the amount of hepatitis C virus (HCV) in the body. Sofosbuvir may not prevent the spread of hepatitis C to other people.

How should this medicine be used?

Sofosbuvir comes as a tablet to take by mouth. It is usually taken with or without food once a day. Take sofosbuvir at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sofosbuvir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take sofosbuvir even if you feel well. Sofosbuvir must be taken in combination with peginterferon alfa and ribavirin or in combination with ribavirin alone. If sofosbuvir is taken in combination with peginterferon alfa and ribavirin, it is usually taken for 12 weeks. If sofosbuvir is taken in combination with ribavirin alone, it is usually taken for 12 or 24 weeks. If you have liver cancer and are waiting for a liver transplant, you will take sofosbuvir with ribavirin for up to 48 weeks or until you have a liver transplant. The length of your treatment depends on your condition, how well you respond to the medication, and whether you experience severe side effects. Do not stop taking sofosbuvir, peginterferon alfa, or ribavirin, unless told to do so by your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking sofosbuvir,

  • tell your doctor and pharmacist if you are allergic to sofosbuvir, any other medications, or any of the ingredients in sofosbuvir tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone), certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenobarbital, or phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); rifapentine (Priftin); or tipranavir (Aptivus). Your doctor may tell you not to take sofosbuvir if you are taking one or more of these medications or monitor you carefully for side effects.
  • tell your doctor what herbal products you are taking, especially St. John’s wort. You should not take St. John’s wort during your treatment with sofosbuvir.
  • tell your doctor if you have had a liver transplant, if you have or have ever had depression or mental illness, human immunodeficiency virus (HIV), kidney disease, or any type of liver disease other than hepatitis C.
  • tell your doctor if you are pregnant, plan to become pregnant, or can possibly become pregnant. If you are male, tell your doctor if your partner is pregnant, plans to become pregnant, or can possibly become pregnant. Sofosbuvir must be taken with ribavirin which can seriously harm the fetus. You must use two methods of birth control to prevent pregnancy in you or your partner during treatment with these medications and for 6 months after your treatment. Talk to your doctor about which methods you should use; hormonal contraceptives (birth control pills, patches, implants, rings, or injections) may not work well in women who are taking these medications. You or your partner must be tested for pregnancy prior to treatment, every month during your treatment, and for 6 months after your treatment. If you or your partner becomes pregnant while taking these medications or within 6 months after your treatment, call your doctor immediately.
  • tell your doctor if you are breastfeeding.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

If you remember the missed dose on the day that you were supposed to take it, take the missed dose as soon as you remember it on that day. However, if you do not remember the missed dose until the next day, skip the missed dose and continue your regular dosing schedule. Do not take two doses on the same day.

What side effects can this medication cause?

Sofosbuvir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  1. diarrhea
  2. headache
  3. muscle pain
  4. difficulty falling asleep or staying asleep
  5. irritability
  6. itching
  7. rash

Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:

  1. pale skin
  2. dizziness
  3. shortness of breath
  4. weakness
  5. sore throat, fever, chills, and other signs of infection
  6. depression
  7. changes in mood or behavior
  8. thoughts of killing or hurting yourself

Sofosbuvir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Additional Information

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