Where to buy and the price of Ledifos
Where to Buy Ledifos is its price. The original drug Harvoni, a native of Israel, will cost the patient at 15,500 INR where Ledifos from India costs 240 dollars (28 tablets).
The price of Ledifos depends on the number of jars (in 1 bottle of 28 tablets):
- 1 bottle – 240 dollars;
- 2 jars (56 tab.) – 450 dollars;
- 3 jars (84 tab.) – 700 dollars;
- more buy – more discount.
Buy Ledifos can be from direct suppliers of medical products from India, as well as in private medical clinics in Russia
Buy Ledifos Tablets (Sofosbuvir and Ledipasvir) is a generic of the drug Harvoni. The Indian company Hetro produces the medicine. To date, India is the leader in the production of generics for antiviral drugs. The quality of Indian products was confirmed not only by doctors and patients, but also by the largest pharmacological companies producing original products.
Ledifos was approved for the treatment of patients with hepatitis C of the first and fourth genotype. It was approved by the US Food and Drug Administration (FDA) as an operating regimen without the use of standard Ribavirin and interferon.
Before the release of the Ledifos preparation, experiments were conducted on a wide scale. Clinical trials have proven efficacy, as well as its low toxicity. One study involved 1500 patients who suffered from hepatitis C of the first genotype.
They took this medicine for twelve weeks. The results of Ledifos treatment were as follows: 1456 patients, that is, the majority, received the desired result. The virus was completely absent in the blood.
The doctors who conducted the studies recorded the only negative side of this course of treatment: patients had mild side effects. They were expressed in the form of headaches and rapid fatigue. It is worth noting that even expensive drugs, like Harvoni, can cause these effects. Therefore, they are not an obstacle to the treatment course.
Composition and therapeutic effect of Ledifos?
The Ledifos drug has two constituent elements: a Ledipasvir in a dosage of 90 milligrams and Sofosbuvir at a dosage of 400 milligrams. Sofosbuvir is used to treat hepatitis C, starting in 2013. Clinical studies have shown that, compared with other drugs, it is more effective, and also has fewer side effects.
Thanks to Sofosbuvir it is possible to shorten the duration of the course of treatment in two to four times. It allows you to completely abandon the use of interferon, which has a number of serious side effects. This drug is included by the World Health Organization in the list of the most important medicines.
Ledipasvir, the dosage of which is less in the preparation of Ledifos, was developed by the pharmacological company Gilead Sayanses. A number of studies have been carried out and in 2014 the efficacy of the combination of Ledipasvir + Sofosbuvir in the treatment of the first genotype of hepatitis C has been confirmed. The combination of these components effectively fights with the replication of the virus. The mechanism of action is inhibitory action against the hepatitis C virus phosphoprotein (NS5A).
The success of Ledifos treatment depends on many factors. However, even patients with cirrhosis get full recovery (after 12 weeks, 99% of patients receive a persistent virologic response). Patients without cirrhosis get a recovery in 97% of recorded cases.
Indications and contraindications to the use of Ledifos?
Ledifos was developed for the treatment of patients with hepatitis C of the first genotype with and without cirrhosis. It is equally effective for those who are just beginning treatment of a viral disease, and for those who have already been treated with other drugs before. It can also be used by those who had an ineffective treatment experience with the inclusion of interferon or ribavirin or there is intolerance of these components.
Ledifos, like any antiviral drug, has a number of contraindications:
- Allergic manifestations on one of the two components (if there were manifestations earlier);
- Pregnancy or lactation period;
- Age to 18 years;
- When taking additional drugs containing Sofosbuvir, an overdose of this component is possible;
- When taking drugs with elvitegravir.
Treatment is contraindicated when taking the following drugs that can neutralize the effect of Ledifos: tenofovir, emtricitabine, rosuvastatin, phenytoin, rifampin, tipranavir, St. John’s Wort. The attending physician should take into account the risks of treatment in the presence of insufficient kidney or liver. Reception of a medicine is possible, however under the constant control.
During the adoption of Ledifos, a woman should take responsibility for taking contraception, since pregnancy is highly undesirable. Clinically, the effect of the drug components on the fetus has not been studied.
There are cases when a woman who has just given birth needs to undergo a course of medicamentous treatment with the Ledifos preparation. In this case, virologists insist on stopping breastfeeding. The medicine is able to penetrate the digestive tract of the baby along with the mother’s milk.
As a rule, children are also not appointed Ledifos. The effectiveness of treatment with this drug, in this case, is not fully understood.
It is worth remembering these rules for the use of the drug:
If you have any allergic reactions to medications, be sure to tell your doctor before starting treatment with Ledifos.
- At the slightest negative reactions of an organism, it is necessary to consult with the doctor.
- You can not independently complement the course of treatment with other antiviral drugs.
- If there is a need to use any other medicine (for example, headache or nausea), first of all, you need to ask advice from your doctor.
Instructions for use of Ledifos
The drug is used in the same way as any other antiviral generic type Harvoni. Instruction for the use of Ladyfoss is as follows:
- Every day you need to take one tablet of the drug.
- Do not chew or crush a pill, you need to drink it with a small amount of still water.
- You need to take the medicine every day at the same time. This enhances the healing effect.
If you suddenly forget to take Ladiphos on time, try to drink it as soon as you remember. You can skip a maximum of one day of treatment, however, taking two tablets immediately is strictly prohibited. Remember that this drug has an antiviral effect, so it can cause nausea or weakness in the body. Do not interrupt treatment if headaches are irregular and not strong. This is included in the concept of the norm when treated with the Ladiphos course.
The choice of the mode of application of the preparation depends on the following factors: the genotype of the virus, the state of the patient’s liver, the previous treatment of the viral disease.
The course of treatment for hepatitis From the first genotype is twelve weeks. If the patient has cirrhosis (compensated), the duration of treatment is doubled (24 weeks). The same goes for patients who undergo a second antiviral course of treatment, and also have a co-infection (HIV, for example).
Individual characteristics of the use of this medication are determined by the treating therapist. If after a full course of treatment there is no virologic response, the doctor interrupts the use of the drug and prescribes a different kind of treatment.
In case of taking two or more tablets of Lediphos, that is, with an overdose, you should immediately consult a doctor and undergo a series of examinations that will determine the concentration of the substance in the body. There were no studies on overdose.
During the course of treatment, you can drive a car, but you should be as careful as possible. The drug can cause fatigue and lethargy in the body. Patients after 60 years of age, as well as those with renal insufficiency, are prescribed a standard dose of the drug.
Side effects when treated with Ledifos
In a short period of time, Ledifos has become widespread not only in Asian countries but also in America and Europe. However, there are also disadvantages of this medication. Side effects of Ladyfos: headaches and migraines, nausea, heaviness in the body, fatigue, allergies.
When you are just starting to take the drug, you should pay attention to any changes in the body. Some doctors even advise to fix them on paper, it helps to analyze the course of the illness and the healing process, as well as plan future therapy. Daily, make negative feelings in the treatment process in your diary.
Itching, swelling of the face or limbs, shortness of breath – all these factors can cause an end to therapy. In order for the doctor to determine the correct cause of the ailment, tell him the time when the seizures began and ended. They can be the primary reaction to antiviral therapy and eventually pass. It is important to know that if the treatment is combined with ribavirin, the number of side effects increases at times.
The medicine is prescribed for patients with cirrhosis of the liver, they must undergo regular medical examination. In 95% of cases, the drug is transferred without complications and gives a quick recovery without consequences