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virem 600

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Darunavir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 3 years of age and older. Darunavir is always used in combination with the HIV medicine ritonavir (brand name: Norvir) and other HIV medicines.

Product Description

What is darunavir?

Darunavir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 3 years of age and older. Darunavir is always used in combination with the HIV medicine ritonavir (brand name: Norvir) and other &nmp HIV medicines.

Darunavir belongs to a class (group) of HIV drugs called protease inhibitors (PIs). PIs block an HIV enzyme called protease. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking protease, PIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.

What should I tell my health care provider before taking darunavir?

What should I tell my health care provider before taking darunavir?

Before taking darunavir, tell your health care provider:

  • If you are allergic to darunavir, sulfa medicines, or any other medicines.
  • If you have liver problems, including hepatitis B virus (HBV) infection or hepatitis C virus (HCV) infection.
  • If you have high blood sugar (hyperglycemia) or diabetes.
  • If you have hemophilia.
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. Whether darunavir can harm an unborn baby is unknown. Talk to your health care provider about possible risks with taking darunavir when pregnant.
  • If you are breastfeeding or plan to breastfeed. &nmp Do not breastfeed if you are infected with HIV or are taking darunavir.
  • If you are using hormone-based birth control (such as pills, implants, or vaginal rings). Darunavir may make these forms of birth control less effective. Your health care provider can help you decide how to adjust your birth control while you are taking darunavir. For more information about using birth control and HIV medicines at the same time, view the AIDSinfo HIV and Birth Controlinfographic.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products (particularly St. John’s Wort) you are taking or plan to take. Darunavir may affect the way other medicines or products work, and other medicines or products may affect how darunavir works. Taking darunavir together with certain medicines or products may cause serious, life-threatening side effects.

What side effects can darunavir cause?

Darunavir may cause side effects. Most side effects from darunavir are manageable, but a few can be serious. Serious side effects of darunavir include liver problems and severe skin reactions or rash. (See the WARNING box above.)

Other possible side effects of darunavir include:

Diabetes and high blood sugar (hyperglycemia).

  • Changes in body fat (including gain or loss of fat).
  • Immune reconstitution inflammatory syndrome (IRIS), a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
  • Increased bleeding in people with hemophilia.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of darunavir. To learn more about possible side effects of darunavir, read the drug label or &nmp package insert or talk to your health care provider or pharmacist.

The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to darunavir.

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