Why is this medication prescribed?
The combination of ledipasvir and sofosbuvir is used to treat chronic hepatitis C (an ongoing viral infection that damages the liver). Sofosbuvir is in a class of antiviral medications called nucleotide polymerase inhibitors. It works by decreasing the amount of hepatitis C virus (HCV) in the body. Ledipasvir is in a class of antiviral medications called HCV NS5A inhibitors. It works by stopping the virus that causes hepatitis C from spreading inside the body.
How should this medicine be used?
The combination of ledipasvir and sofosbuvir comes as a tablet to take by mouth. It is usually taken with or without food once daily. Take ledipasvir and sofosbuvir at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ledipasvir and sofosbuvir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take ledipasvir and sofosbuvir even if you feel well. The length of your treatment (8 to 24 weeks) depends on your condition, how well you respond to the medication, and whether you experience severe side effects. Do not stop taking ledipasvir and sofosbuvir without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking ledipasvir and sofosbuvir,
- tell your doctor and pharmacist if you are allergic to ledipasvir or sofosbuvir, any other medications, or any of the ingredients in ledipasvir and sofosbuvir tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone), certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), oxcarbazepine (Oxtellar XR, Trileptal), phenobarbital, or phenytoin (Dilantin, Phenytek); digoxin (Lanoxin), medications for heartburn and ulcers; medications for HIV taken together such as efavirenz (Sustiva, in Atripla), emtricitabine (Emtriva, in Atripla) and tenofovir (Viread, in Atripla); elvitegravir (Sustiva, in Atripla), cobicistat (Tybost, in Stribild), emtricitabine (Emtriva, in Stribild), and tenofovir (Viread, in Stribild); tenofovir (Viread), atazanavir (Reyataz) and ritonavir (Norvir); tenofovir (Viread), darunavir (Prezista) and ritonavir (Norvir); tenofovir (Viread), lopinavir (in Kaletra), and ritonavir (Norvir, in Kaletra); or tipranavir (Aptivus) and ritonavir (Norvir); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); rifapentine (Priftin); rosuvastatin (Crestor); simeprevir (Olysio); and sofosbuvir (Solvaldi). Your doctor may tell you not to take ledipasvir and sofosbuvir if you are taking one or more of these medications or may monitor you carefully for side effects.
- if you are taking antacids containing aluminum hydroxide or magnesium hydroxide (Maalox, Mylanta, Tums, others), take them 4 hours before or 4 hours after taking ledipasvir and sofosbuvir.
- tell your doctor what herbal products you are taking, especially St. John’s wort. You should not take St. John’s wort during your treatment with ledipasvir and sofosbuvir.
- tell your doctor if you have or have ever had kidney disease or any type of liver disease other than hepatitis C.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking ledipasvir and sofosbuvir, call your doctor.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Ledipasvir and sofosbuvir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- difficulty falling asleep or staying asleep
Ledipasvir and sofosbuvir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.